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KMID : 0191120110260081052
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Journal of Korean Medical Science
2011 Volume.26 No. 8 p.1052 ~ p.1060
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Relationship between Coronary Artery Calcium Score by Multidetector Computed Tomography and Plaque Components by Virtual Histology Intravascular Ultrasound
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Choi Yun-Ha
Hong Young-Joon
Park In-Hyae
Jeong Myung-Ho
Ahmed Khurshid
Hwang Seung-Hwan
Lee Min-Goo
Park Keun-Ho
Sim Doo-Sun
Kim Ju-Han
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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The aim of this study was to evaluate the relationship between coronary artery calcium score (CACS) assessed by multidetector computed tomography (MDCT) and plaque components assessed by virtual histology-intravascular ultrasound (VH-IVUS) in 172 coronary artery disease (CAD) patients with 250 coronary lesions. CACS was assessed according to Agatston scoring method by MDCT and patients were divided into four groups: Group I (CACS = 0 [n = 52]); Group II (CACS = 1-100 [n = 99]); Group III (CACS = 101-400 [n = 84]); and Group IV (CACS > 400 [n = 15]). Total atheroma volume was greatest in Group IV (152 ± 132 μL vs 171 ± 114 μL vs 195 ± 149 μL vs 321±182 μL, P < 0.001). The absolute dense calcium (DC) and necrotic core (NC) volumes were greatest, and relative DC volume was greatest in Group IV (5.5 ± 6.6 μL vs 11.0 ± 10.3 μL vs 15.6 ± 13.6 μL vs 36.6 ± 18.2 μL, P < 0.001, and 14.8 ± 18.2 μL vs 19.5 ± 18.9 μL vs 22.5 ± 19.1 μL vs 41.7 ± 27.9 μL, P < 0.001, and 6.4 ± 5.3% vs 11.0 ± 6.2% vs 14.0 ± 6.5% vs 20.0 ± 7.8%, P < 0.001, respectively). The absolute plaque and DC and NC volumes and the relative DC volume correlated positively with calcium score. CAD patients with high calcium score have more vulnerable plaque components (greater DC and NC-containing plaques) than those with low calcium score.
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KEYWORD
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Coronary Disease, Multidetector Computed Tomography, Coronary Artery Calcium Score, Plaque, Intravascular Ultrasound
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